The Role of Exercise in the Alleviation of Neuropathic Pain Following Traumatic Spinal Cord Injuries: A Systematic Review and Meta-analysis

Objective: The objective of this systematic review and meta-analysis was to assess the efficacy exercise in neuropathic pain following traumatic spinal cord injuries.Methods: search conducted MEDLINE, Embase, Scopus, Web Science by end 2022. Two independent researchers included articles based on inclusion exclusion criteria. A standardized mean difference calculated for each data they were pooled calculate an overall effect size. To heterogeneity between studies, I<sup>2</sup> chi-square tests utilized. In case heterogeneity, meta-regression performed identify potential source.Results: Fifteen preclinical studies included. Meta-analysis demonstrated that significantly improves mechanical allodynia (standardized [SMD], -1.59; 95% confidence interval [CI], -2.16 -1.02; p < 0.001; = 90.37%), thermal hyperalgesia (SMD, 1.95; CI, 0.96–2.94; 0.001), cold -2.92; -4.4 -1.43; 0.001). improvement is more animals with a compression model SCI (meta-regression coefficient, -1.33; -1.84 -0.57; 0.001) mild (p Additionally, prominent if training started 7 8 days postinjury (coefficient, -2.54; -3.85 -1.23; continued every day -1.99; -3.07 -0.9; Likewise, voluntary size -1.45; -2.67 -0.23; 0.02).Conclusion: Exercise effective amelioration pain. This voluntary, continuous initiated subacute phase SCI.